In eukaryotic cells, proteins destined for secretion follow a strictly coordinated endomembrane pathway from their initial synthesis to extracellular release. Arrange the following stages of the secretory pathway in the correct chronological order from start to finish.
- 1Translation and co-translational translocation of the nascent polypeptide into the lumen of the rough endoplasmic reticulum
- 2Packaging of correctly folded proteins into transport vesicles and transfer from the endoplasmic reticulum to the cis-Golgi face
- 3Biochemical modification, glycosylation processing, and molecular sorting across the Golgi cisternae toward the trans-Golgi network
- 4Condensation and budding of mature secretory transport vesicles from the trans-Golgi network toward the cell periphery
- 5Fusion of secretory vesicles with the plasma membrane to release cargo proteins into the extracellular space via exocytosis
Cevap
The correct chronological order begins with translation and translocation into the rough endoplasmic reticulum, followed by vesicular transfer to the cis-Golgi, modification across the Golgi cisternae, packaging into secretory vesicles at the trans-Golgi network, and ends with exocytosis at the plasma membrane.
In eukaryotic cells, the secretory pathway operates in a strict unidirectional sequence: nascent proteins are translocated into the rough endoplasmic reticulum lumen, exported in transport vesicles to the cis-Golgi network, processed through the Golgi cisternae to the trans-Golgi network, pinched off into secretory vesicles, and released externally via plasma membrane exocytosis.
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Eukaryotic Endomembrane Secretory Pathway
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