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Zorluk: KolayPsychopharmacology and Psychological Therapies

Match each patient's clinical presentation with the most appropriate pharmacological treatment based on their specific comorbidities and side effect profiles.

  • A 24-year-old patient with major depressive disorder who is highly motivated to quit smoking and wishes to avoid medication-induced sexual dysfunction.Bupropion
  • A 78-year-old patient with severe major depressive disorder, profound weight loss, and chronic insomnia.Mirtazapine
  • A 32-year-old patient with bipolar I disorder requiring maintenance pharmacotherapy who has concurrent severe hepatic disease.Lithium
  • A 28-year-old patient with schizophrenia requiring antipsychotic treatment who previously developed severe galactorrhea and amenorrhea on risperidone.Aripiprazole

Cevap

The clinical presentations match properly to Bupropion (for smoking cessation/no sexual side effects), Mirtazapine (for insomnia/weight loss), Lithium (for hepatic disease), and Aripiprazole (to avoid hyperprolactinemia).
Each correct pairing takes into account the specific mechanism of action and side effect profile of the medication, aligning it with the patient's unique comorbidities and treatment goals.

Adım Adım Çözüm

1
Analyze the needs of the 24-year-old patient with depression.
The patient needs an antidepressant that assists with smoking cessation and lacks sexual side effects.
Bupropion uniquely fits this profile as an NDRI.
2
Evaluate the symptoms of the 78-year-old patient.
The patient has depression complicated by weight loss and insomnia.
Mirtazapine provides therapeutic benefits for all three issues due to its noradrenergic and specific serotonergic activity, plus antihistaminic effects.
3
Assess the medical comorbidities of the 32-year-old patient with bipolar disorder.
The patient has severe hepatic disease.
Lithium is renally cleared and thus safe in hepatic impairment, whereas valproate is hepatically metabolized and potentially hepatotoxic.
4
Review the previous adverse effects in the 28-year-old patient with schizophrenia.
The patient developed hyperprolactinemia on risperidone.
Aripiprazole, a D2 partial agonist, minimizes prolactin elevation and can even lower prolactin levels compared to typical agents.

Anahtar Kavram

Selection of psychotropic medications based on side effect profiles, comorbidities, and specific therapeutic benefits.
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