A -year-old man comes to the clinic reporting a -month history of worsening fatigue, generalized weakness, and decreased libido. He has also been experiencing intermittent, dull headaches and occasional blurry vision, especially when driving. He does not take any medications. Vital signs are within normal limits. Physical examination reveals delayed relaxation phase of the deep tendon reflexes. Visual field testing by confrontation demonstrates decreased peripheral vision bilaterally.
Laboratory results are as follows:
Thyroid-stimulating hormone (TSH): U/mL (Normal: U/mL)
Free thyroxine (T4): ng/dL (Normal: ng/dL)
Testosterone, total: ng/dL (Normal: ng/dL)
Luteinizing hormone (LH): mIU/mL (Normal: mIU/mL)
Which of the following is the most likely underlying mechanism for this patient's thyroid laboratory findings?
- AAutoimmune infiltration of the thyroid gland
- Decreased production of thyrotropinCevap
- CImpaired peripheral deiodination of thyroxine
- DTissue resistance to thyroid hormone
- EIncreased concentration of thyroxine-binding globulin