Examkin

Soru

Zorluk: KolayRheumatology and Immunology

Match each specific autoantibody profile with its most strongly associated rheumatologic condition.

  • Anti-double-stranded DNA (anti-dsDNA)Systemic lupus erythematosus (SLE)
  • Anti-centromere antibodyLimited cutaneous systemic sclerosis
  • Anti-Jo-1 antibodyPolymyositis / Dermatomyositis
  • Anti-cyclic citrullinated peptide (anti-CCP)Rheumatoid arthritis

Cevap

The correct pairings are: Anti-dsDNA matches with Systemic lupus erythematosus (SLE); Anti-centromere matches with Limited cutaneous systemic sclerosis; Anti-Jo-1 matches with Polymyositis / Dermatomyositis; Anti-CCP matches with Rheumatoid arthritis.
Each autoantibody listed has a distinct, classic disease association commonly tested on the USMLE. Anti-dsDNA is specific for SLE, anti-centromere for limited systemic sclerosis, anti-Jo-1 for inflammatory myopathies, and anti-CCP for rheumatoid arthritis. Recognizing these fundamental associations is essential for diagnosing systemic autoimmune disorders.

Adım Adım Çözüm

1
Identify the target disease for anti-dsDNA.
Systemic lupus erythematosus (SLE).
Anti-dsDNA is a classic, highly specific diagnostic marker for SLE.
2
Identify the target disease for anti-centromere antibodies.
Limited cutaneous systemic sclerosis.
This antibody is uniquely linked to the limited cutaneous subtype of scleroderma.
3
Identify the target disease for anti-Jo-1 antibodies.
Polymyositis / Dermatomyositis.
Anti-Jo-1 targets histidyl-tRNA synthetase and is classically seen in these inflammatory myopathies.
4
Identify the target disease for anti-CCP.
Rheumatoid arthritis.
Anti-CCP is the most specific serologic test available for diagnosing rheumatoid arthritis.

Anahtar Kavram

Serologic autoantibody profiles in specific rheumatologic diseases
Bu soruyu puanla

Konular

Rheumatology and Immunology

Bu konudan daha fazla soru