An infertility evaluation is initiated for a couple who have been unable to achieve a pregnancy despite having regular, unprotected intercourse for the past months. The female partner is years of age. She reports that since discontinuing oral contraceptive pills a year and a half ago, she has not experienced a single menstrual period. Prior to starting oral contraceptives at age , her menstrual cycles occurred irregularly every to months. She competes in triathlons and maintains a strict vegan diet. Her body mass index is . Vital signs show a blood pressure of and a pulse of . Physical examination reveals Tanner stage V breast development and normal pubic hair, with no hirsutism, acne, or thyromegaly. Pelvic ultrasound demonstrates a normal-appearing uterus with a thin endometrial stripe () and small, bilateral ovaries without cysts. Laboratory evaluation shows:
| Test | Result |
|---|---|
| -hCG | Negative |
| Follicle-stimulating hormone | |
| Luteinizing hormone | |
| Estradiol | |
| Thyroid-stimulating hormone | |
| Prolactin |
After months of concerted efforts at nutritional rehabilitation and exercise reduction, her body mass index remains and her amenorrhea persists. Which of the following is the most appropriate next step in medical management to help this patient conceive?
- Exogenous gonadotropin therapyCevap
- BLetrozole therapy
- CClomiphene citrate therapy
- DCabergoline administration
- ELevothyroxine supplementation