A medical student is reviewing pathologic specimens during a pediatric hematology and oncology rotation. Match each described histologic or peripheral blood smear finding with the most appropriate diagnosis.
- Bone marrow aspirate reveals atypical promyelocytes with deeply lobated nuclei and multiple, needle-like cytoplasmic inclusions.Acute Promyelocytic Leukemia
- Lymph node biopsy displays large, binucleated cells with prominent eosinophilic nucleoli within a mixed inflammatory background.Classical Hodgkin Lymphoma
- Tissue biopsy shows a high-grade proliferation of medium-sized lymphoid cells interspersed with numerous tingible body macrophages.Burkitt Lymphoma
- Peripheral blood smear demonstrates normochromic, normocytic red blood cells with small, round, basophilic nuclear remnants.Sickle Cell Disease
Cevap
Atypical promyelocytes with Auer rods matches Acute Promyelocytic Leukemia. Binucleated cells with prominent nucleoli matches Classical Hodgkin Lymphoma. Medium-sized cells with tingible body macrophages matches Burkitt Lymphoma. Basophilic nuclear remnants (Howell-Jolly bodies) matches Sickle Cell Disease.
Each pediatric hematology/oncology diagnosis listed has a highly specific morphologic finding. Acute promyelocytic leukemia presents with numerous Auer rods; Classical Hodgkin lymphoma features Reed-Sternberg cells; Burkitt lymphoma demonstrates a 'starry sky' pattern due to macrophages clearing apoptotic debris; and Sickle Cell disease causes early functional asplenia, preventing the removal of Howell-Jolly bodies from red blood cells.
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Anahtar Kavram
Pathognomonic histologic and peripheral smear findings in pediatric hematology and oncology.