Match each clinical scenario involving a potential infectious exposure with the most appropriate post-exposure prophylaxis (PEP) or management strategy.
- A 26-year-old healthcare worker sustains a needlestick injury from a patient with HIV (viral load 50,000 copies/mL) and Hepatitis C. The worker's Hepatitis B surface antibody titer is adequate.Tenofovir-emtricitabine plus raltegravir for 28 days
- A 19-year-old college student who is currently asymptomatic reports that her dorm roommate was hospitalized yesterday with confirmed Neisseria meningitidis meningitis.Single dose of oral ciprofloxacin or a 2-day course of oral rifampin
- A 42-year-old unvaccinated man is bitten by an unprovoked stray dog in a rural area; the animal fled immediately and cannot be observed or tested for rabies.Rabies immune globulin and rabies vaccine series
- A 30-year-old pregnant woman at 20 weeks gestation, with no history of chickenpox and a negative varicella IgG titer, has a child at home who just developed varicella.Varicella-zoster immune globulin (VZIG)
Cevap
The healthcare worker requires a 3-drug HIV antiretroviral regimen. The college student requires oral ciprofloxacin or rifampin. The unvaccinated man bitten by a dog requires rabies immune globulin and the vaccine series. The pregnant woman exposed to varicella requires Varicella-zoster immune globulin (VZIG).
Each clinical scenario represents a distinct infectious exposure that requires a specific prophylactic regimen based on current clinical guidelines to prevent the development or transmission of the disease.
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Anahtar Kavram
Post-exposure prophylaxis protocols for common infectious diseases