A medical student on a psychiatry clerkship is reviewing the adverse effect profiles of commonly prescribed psychiatric medications. Match each of the following psychotropic medications to the clinical vignette that best describes its characteristic adverse effect or toxicity.
- ClozapinePresents with a high fever, severe pharyngitis, and a dangerously low absolute neutrophil count.
- LamotrigineDevelops a life-threatening maculopapular rash with blistering and mucosal involvement, often following rapid dose titration.
- LithiumExhibits polyuria, polydipsia, and ataxia progressing to delirium, often precipitated by concurrent use of thiazide diuretics.
- BupropionExperiences a generalized tonic-clonic seizure, a risk that is particularly elevated in patients with a history of bulimia nervosa.
- ZiprasidoneAsymptomatic but found to have significant QTc interval prolongation on a screening electrocardiogram.
Cevap
Clozapine matches with agranulocytosis; Lamotrigine matches with Stevens-Johnson syndrome; Lithium matches with toxicity exacerbated by thiazides; Bupropion matches with seizures in eating disorders; Ziprasidone matches with QTc prolongation.
Each psychotropic medication has a unique, high-yield adverse effect profile that must be recognized to ensure patient safety. Clozapine requires strict ANC monitoring due to agranulocytosis risk. Lamotrigine must be titrated slowly to prevent Stevens-Johnson syndrome. Lithium has a narrow therapeutic window, and toxicity is easily precipitated by volume depletion or thiazides. Bupropion lowers the seizure threshold and is contraindicated in eating disorders. Ziprasidone is strongly associated with QTc prolongation.
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Anahtar Kavram
Psychotropic Medication Adverse Effects