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Zorluk: OrtaMeasures of Disease Frequency and Association

A public health department conducts a 10-year prospective cohort study to evaluate the association between a diet high in ultra-processed foods and the development of metabolic syndrome. The study enrolls 10,000 healthy adults without pre-existing metabolic conditions. Participants are categorized into two groups based on detailed dietary questionnaires. Over the 10-year follow-up period, the occurrence of new metabolic syndrome diagnoses is recorded. The results are summarized in the table below:

Dietary PatternDeveloped Metabolic SyndromeDid Not Develop Metabolic SyndromeTotal
High ultra-processed food consumption4004,6005,000
Low ultra-processed food consumption1504,8505,000

Based on these study results, what percentage of metabolic syndrome cases among the participants with high consumption of ultra-processed foods can be attributed to their dietary pattern?

Cevap: 62.5 %

Cevap

62.5
The question asks for the percentage of disease cases among the exposed population that can be specifically attributed to the exposure. This is the definition of the Attributable Risk Percent (ARP), also known as the etiologic fraction. It is calculated using the formula: ARP=Iexposed−IunexposedIexposed×100ARP = \frac{I_{exposed} - I_{unexposed}}{I_{exposed}} \times 100, or alternatively ARP=RR−1RR×100ARP = \frac{RR - 1}{RR} \times 100. Using the incidence data from the table: Iexposed=0.08I_{exposed} = 0.08 and Iunexposed=0.03I_{unexposed} = 0.03. Therefore, ARP=0.08−0.030.08×100=62.5%ARP = \frac{0.08 - 0.03}{0.08} \times 100 = 62.5\%.

Adım Adım Çözüm

1
Calculate the incidence of metabolic syndrome in the exposed group (high ultra-processed diet).
4005,000=0.08\frac{400}{5,000} = 0.08
The incidence in the exposed group (IexposedI_{exposed}) is required to determine the baseline risk associated with the exposure.
2
Calculate the incidence of metabolic syndrome in the unexposed group (low ultra-processed diet).
1505,000=0.03\frac{150}{5,000} = 0.03
The incidence in the unexposed group (IunexposedI_{unexposed}) provides the baseline risk without the primary exposure.
3
Calculate the Attributable Risk (AR).
0.08−0.03=0.050.08 - 0.03 = 0.05
AR represents the excess absolute risk of the disease directly tied to the exposure.
4
Calculate the Attributable Risk Percent (ARP).
(0.050.08)×100=62.5%(\frac{0.05}{0.08}) \times 100 = 62.5\%
ARP represents the proportion of disease cases among the exposed that are specifically attributable to the exposure.

Anahtar Kavram

Attributable Risk Percent (ARP)
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Measures of Disease Frequency and Association

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