A -year-old man presents via telehealth for an initial psychiatric evaluation. He reports a -week history of persistent low mood, extreme lethargy, and a -kg (-lb) weight gain. He sleeps up to hours a day and describes his limbs as feeling 'unnaturally heavy.' For the past weeks, he has also been hearing a distinct, critical voice telling him he is 'toxic and contagious' whenever he is alone in his room. Upon detailed psychiatric history taking, he reveals that years ago, he was hospitalized for a -day period during which he believed he was a divine messenger, slept only hour per night, and paced the streets preaching. He was stabilized and discharged but stopped his prescribed medications shortly afterward. He recently began taking a high-dose over-the-counter St. John's wort supplement to improve his mood, but it has provided no relief. A recent primary care blood panel shows a thyroid-stimulating hormone (TSH) level of mU/L (normal: -) and a free thyroxine (T4) level of ng/dL (normal: -). Which of the following is the most appropriate next step in the management of this patient?
- Discontinue St. John's wort and initiate quetiapineCevap
- BDiscontinue St. John's wort and initiate fluoxetine monotherapy
- CAdd phenelzine to his current supplement regimen
- DDiagnose schizophreniform disorder and initiate haloperidol
- EInitiate levothyroxine therapy to correct underlying metabolic dysfunction