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Zorluk: OrtaRheumatology and Immunology

Match each clinical presentation with the most likely rheumatologic diagnosis.

  • A young male patient complains of insidious-onset lower back pain that awakens him in the second half of the night but improves significantly after physical activity.Ankylosing spondylitis
  • A middle-aged female patient notes the gradual development of bilateral wrist and metacarpophalangeal joint swelling, accompanied by prolonged stiffness upon waking.Rheumatoid arthritis
  • A previously healthy male patient develops acute, asymmetric swelling of his right knee and left heel, along with dysuria and eye redness, shortly after a diarrheal illness.Reactive arthritis
  • A patient with scaly, erythematous skin plaques develops asymmetric oligoarthritis and dactylitis of the toes, alongside noticeable pitting of the fingernails.Psoriatic arthritis

Cevap

The correct matches align each clinical vignette with its classic inflammatory arthropathy presentation: Ankylosing spondylitis (inflammatory back pain improving with exercise), Rheumatoid arthritis (symmetric polyarthritis with morning stiffness), Reactive arthritis (post-infectious triad), and Psoriatic arthritis (dactylitis and nail changes with skin plaques).
Each diagnosis represents a distinct rheumatologic condition with classic manifestations. Ankylosing spondylitis presents with inflammatory back pain. Rheumatoid arthritis presents with symmetric inflammatory polyarthritis of the hands. Reactive arthritis follows an infection with a classic triad. Psoriatic arthritis features dactylitis and nail changes alongside skin lesions.

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1
Analyze the first vignette describing back pain that improves with exercise and worsens at night in a young male.
Identified as inflammatory back pain, which is the hallmark of axial spondyloarthritis.
This presentation differentiates inflammatory back pain (Ankylosing spondylitis) from mechanical back pain (which typically worsens with activity).
2
Analyze the second vignette describing symmetric small-joint polyarthritis with morning stiffness.
Identified as the classic presentation of Rheumatoid arthritis.
Rheumatoid arthritis classically affects the metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints symmetrically and features prolonged inflammatory stiffness.
3
Analyze the third vignette describing asymmetric oligoarthritis, urethritis, and conjunctivitis after an infection.
Identified as Reactive arthritis.
This is the classic post-infectious triad previously known as Reiter syndrome, strongly associated with HLA-B27.
4
Analyze the fourth vignette describing dactylitis, nail pitting, and skin plaques.
Identified as Psoriatic arthritis.
Nail changes and dactylitis ('sausage digits') in the presence of psoriatic skin lesions are highly specific for Psoriatic arthritis.

Anahtar Kavram

Clinical presentation and differentiation of major inflammatory arthropathies, including rheumatoid arthritis and the seronegative spondyloarthropathies.
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