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Zorluk: KolayMeasures of Disease Frequency and Association

A population health researcher is analyzing the long-term respiratory effects of chronic silica dust exposure among mining personnel. A registry of 3,0003,000 miners is reviewed over a 1515-year period. The data show that out of 1,0001,000 miners who were routinely exposed to high levels of silica dust, 200200 developed pulmonary fibrosis. Among the 2,0002,000 miners who worked in administrative roles without silica exposure, 100100 developed pulmonary fibrosis. Based on this cohort data, what is the relative risk of developing pulmonary fibrosis for those exposed to silica dust compared to those who were not exposed?

  1. A
    0.150.15
  2. B
    0.250.25
  3. C
    2.02.0
  4. 4.04.0Cevap
  5. E
    4.754.75

Cevap

The relative risk is 4.04.0.
Relative risk (RR) is calculated by dividing the incidence of the disease in the exposed group by the incidence in the unexposed group. In this scenario, the incidence of pulmonary fibrosis in the exposed group is 200/1,000=0.20200 / 1,000 = 0.20. The incidence in the unexposed group is 100/2,000=0.05100 / 2,000 = 0.05. Therefore, the relative risk is 0.20/0.05=4.00.20 / 0.05 = 4.0. This means that miners exposed to silica dust are 44 times more likely to develop pulmonary fibrosis compared to those who are not exposed.

Adım Adım Çözüm

1
Calculate the incidence of the disease in the exposed group.
200/1,000=0.20200 / 1,000 = 0.20 (or 20%20\%).
Relative risk requires comparing the absolute risk (incidence) in both the exposed and unexposed populations.
2
Calculate the incidence of the disease in the unexposed group.
100/2,000=0.05100 / 2,000 = 0.05 (or 5%5\%).
This establishes the baseline risk in the population without the exposure.
3
Divide the incidence in the exposed group by the incidence in the unexposed group.
0.20/0.05=4.00.20 / 0.05 = 4.0.
Relative Risk (RR) is the ratio of these two incidences, indicating how many times more likely the exposed group is to develop the disease.

Anahtar Kavram

Relative Risk (RR) calculation in a cohort study
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