A -month-old boy is brought to the pediatric clinic for a routine well-child visit. His mother is concerned because he is not yet walking independently and his vocabulary consists of only a single word. He was born at weeks gestation without perinatal complications, and newborn screening was reported as normal. A review of his growth chart demonstrates that his length has decreased from the th percentile at months of age to the th percentile currently, while his weight has remained steady along the th percentile. Vital signs include a temperature of (), heart rate of /min, and respiratory rate of /min. Physical examination reveals an infant with a persistently open and large anterior fontanelle, generalized hypotonia, and delayed relaxation of the deep tendon reflexes. Laboratory evaluation shows:
Thyroid-stimulating hormone (TSH): (Normal: )
Free thyroxine (T4): (Normal: )
Which of the following is the most appropriate next step in the evaluation of this patient?
- AThyroid peroxidase antibody testing
- BReassurance and reevaluation of development in three months
- CLumbar puncture and empirical intravenous antibiotics
- Magnetic resonance imaging of the brainCevap
- EMeasurement of serum -hydroxyprogesterone levels