A clinical study evaluates a novel prophylactic drug for episodic tension-type headaches among 200 adult participants over a 6-month period. Participants are equally divided into two groups. In the group receiving the standard placebo, 30 out of 100 participants experience a severe headache episode. In the group receiving the novel prophylactic drug, 10 out of 100 participants experience a severe headache episode. Based on these findings, what is the number needed to treat (NNT) to prevent one severe headache episode?
Cevap: 5 patients
Cevap
5
The Number Needed to Treat (NNT) is the number of patients who must receive a particular therapy for one additional patient to benefit. It is calculated as 1 divided by the Absolute Risk Reduction (ARR). In this study, the ARR is the difference between the control event rate (30%) and the experimental event rate (10%), which equals 20% (0.20). Therefore, the NNT is .
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Anahtar Kavram
The Number Needed to Treat (NNT) is calculated as the inverse of the Absolute Risk Reduction (), representing the number of patients that must be treated to prevent one additional adverse outcome.