During a routine wellness examination, a -year-old woman is found to have an asymmetric thyroid gland. She reports feeling generally well, though she notes a mild increase in anxiety and occasional loose stools over the past two months. Her heart rate is and blood pressure is . Physical examination reveals a non-tender, mobile, cm nodule in the right lobe of the thyroid gland. There is no palpable cervical lymphadenopathy. Laboratory testing reveals:
Thyroid-stimulating hormone (TSH): (normal: )
Free thyroxine (T4): (normal: )
A neck ultrasound confirms a cm solid, hypoechoic right-sided thyroid nodule with increased internal vascularity. Which of the following is the most appropriate next step in the management of this patient?
- Radionuclide thyroid scintigraphyCevap
- BFine-needle aspiration biopsy
- CRight thyroid lobectomy
- DMeasurement of serum thyroglobulin
- EObservation with repeat ultrasound in months
Cevap
Radionuclide thyroid scintigraphy
In the evaluation of a newly discovered thyroid nodule, the initial step is to measure serum TSH. If the TSH is subnormal (suppressed), the next required step is radionuclide thyroid scintigraphy (typically using Iodine-123 or Technetium-99m). This test determines whether the nodule is autonomously functioning ('hot') or non-functioning ('cold'). A functioning nodule in the setting of hyperthyroidism (toxic adenoma) has a very low risk of malignancy and typically does not require a fine-needle aspiration (FNA) biopsy, whereas a 'cold' nodule requires further evaluation with FNA to rule out malignancy.
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The diagnostic algorithm for a thyroid nodule relies heavily on the initial TSH level; a subnormal TSH mandates radionuclide scintigraphy before considering fine-needle aspiration.
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