A 64-year-old man presents to the emergency department due to a 2-week history of progressive dyspnea on exertion, orthopnea, and a persistent dry cough. His medical history includes seropositive rheumatoid arthritis, type 2 diabetes mellitus, and a 35-pack-year smoking history. His joint disease was previously inadequately controlled with methotrexate monotherapy, prompting the addition of adalimumab 6 months ago, which has successfully induced clinical remission.
On physical examination, his temperature is (), blood pressure is , heart rate is , and respiratory rate is . Pulse oximetry shows on room air. Jugular venous distention is prominent up to the angle of the mandible while the patient is seated at a 45-degree angle. Auscultation reveals diffuse bilateral expiratory wheezes and coarse crackles at the lung bases. Bilateral 2+ pitting edema is noted up to the mid-calves.
Laboratory results:
Leukocytes:
Hemoglobin:
Brain natriuretic peptide (BNP): (Normal )
Thyroid-stimulating hormone (TSH): (Normal )
Arterial blood gas (room air):
pH:
:
:
:
Which of the following is the most appropriate next step in management?
- Discontinue adalimumab and initiate intravenous furosemideCevap
- BAdminister systemic corticosteroids, nebulized ipratropium-albuterol, and oral azithromycin
- CStart empirical intravenous piperacillin-tazobactam and vancomycin
- DAdminister intravenous sodium bicarbonate to correct the metabolic derangement
- EInitiate oral levothyroxine and order a transthoracic echocardiogram