Match each patient's clinical presentation with the autoantibody most specific to or characteristic of their underlying diagnosis.
- A 32-year-old woman with recurrent second-trimester miscarriages, a new left lower extremity deep vein thrombosis, and an isolated prolonged partial thromboplastin time.Anticardiolipin antibodies
- A 45-year-old woman with chronic fatigue, difficulty swallowing solid foods, thickened skin confined to her fingers and face, and severe episodic digital pallor in cold weather.Anti-centromere antibodies
- A 55-year-old woman with progressive difficulty standing from a seated position, an erythematous periorbital rash, and violaceous, scaling papules over her metacarpophalangeal joints.Anti-Jo-1 antibodies
- A 40-year-old woman with a chronic sensation of 'sand in the eyes,' the need to drink water to swallow dry foods, and bilateral parotid gland enlargement.Anti-Ro/SSA antibodies
- A 28-year-old woman with a photosensitive facial rash sparing the nasolabial folds, pleuritic chest pain, diffuse joint aches, and new-onset proteinuria.Anti-double-stranded DNA (anti-dsDNA) antibodies
Cevap
The clinical vignettes match as follows: Antiphospholipid syndrome with Anticardiolipin antibodies, Limited cutaneous systemic sclerosis with Anti-centromere antibodies, Dermatomyositis with Anti-Jo-1 antibodies, Sjögren syndrome with Anti-Ro/SSA antibodies, and Systemic Lupus Erythematosus with Anti-double-stranded DNA antibodies.
Each autoantibody represents a highly specific serologic marker for the respective clinical syndrome, confirming the diagnosis based on the classic physical and historical findings provided in the vignettes.
Adım Adım Çözüm
Anahtar Kavram
Serologic markers and autoantibody profiles of systemic autoimmune and rheumatologic diseases.