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Zorluk: OrtaNeurocognitive Disorders

A 72-year-old woman is evaluated in the outpatient geriatric clinic due to progressive memory impairment and behavioral changes. According to her son, who accompanies her, she has experienced significant day-to-day fluctuations in her alertness and attention over the last 10 months. Furthermore, she frequently describes seeing detailed, silent figures of people standing in her bedroom. Her sleep is often restless, and she frequently shouts and thrashes her arms as if she is acting out her dreams. On physical examination, the patient has a mask-like facial expression, a resting tremor in her left hand, and cogwheel rigidity in both upper extremities. The physician explains the likely diagnosis to the son and discusses management options. The physician strongly cautions against the use of a specific class of medications to treat her perceptual disturbances, noting that it could trigger a severe, potentially fatal reaction characterized by irreversible parkinsonism and autonomic dysfunction. Which of the following medications is most likely to cause the severe reaction described by the physician?

  1. HaloperidolCevap
  2. B
    Quetiapine
  3. C
    Donepezil
  4. D
    Carbidopa-levodopa
  5. E
    Clonazepam

Cevap

Haloperidol
This patient's clinical presentation is classic for Dementia with Lewy bodies (DLB), which is characterized by fluctuating cognition, recurrent well-formed visual hallucinations, REM sleep behavior disorder (acting out dreams), and spontaneous parkinsonism. A hallmark feature of DLB is severe neuroleptic sensitivity. Administration of first-generation (typical) antipsychotics, such as haloperidol, or some second-generation antipsychotics with strong dopamine D2 antagonism (e.g., risperidone), can precipitate a life-threatening reaction. This reaction is characterized by a dramatic worsening of parkinsonism, severe muscle rigidity, autonomic instability, and impaired consciousness. Because of this high risk, typical antipsychotics like haloperidol are strictly contraindicated in patients with DLB.

Adım Adım Çözüm

1
Identify the underlying diagnosis based on the clinical presentation.
The patient has fluctuating cognition, well-formed visual hallucinations, REM sleep behavior disorder, and spontaneous parkinsonism, which are core clinical features of Dementia with Lewy bodies (DLB).
Accurate diagnosis is required to understand disease-specific pharmacological contraindications.
2
Recognize the specific pharmacological vulnerability associated with this condition.
Patients with DLB have extreme sensitivity to dopamine D2 receptor antagonists, particularly first-generation (typical) antipsychotics.
Administration of these agents can precipitate a life-threatening reaction known as severe neuroleptic sensitivity.
3
Select the medication from the options that represents this contraindicated class.
Haloperidol is a high-potency typical antipsychotic, making it highly likely to cause severe neuroleptic sensitivity in a patient with DLB.
The other medications listed are either indicated for DLB symptoms or do not cause this specific life-threatening reaction.

Anahtar Kavram

Severe neuroleptic sensitivity in Dementia with Lewy bodies (DLB)
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