A -year-old woman comes to the clinic for evaluation of profound fatigue, proximal muscle weakness, and progressive facial hair growth over the past months. Her menstrual periods occur only once every to months. She also reports severe mood swings. Three months ago, a different physician started her on fluoxetine monotherapy for depression; shortly after, she experienced a -day period of rapid speech, grandiosity, and a decreased need for sleep before returning to a depressed state.
She brings laboratory results from an outside wellness clinic. They performed a novel serum biomarker test for 'adrenal malignancies.' The test has a sensitivity of and a specificity of . The prevalence of adrenal malignancy in her age group is . The test result was positive, and she is terrified that she has cancer.
Vital signs are temperature (), blood pressure mmHg, pulse /min, and BMI . Physical examination reveals a plethoric face, prominent coarse hair on the chin, and multiple -cm wide violaceous striae on the lower abdomen.
Laboratory results:
TSH: (Normal: )
Free T4: (Normal: )
Testosterone, total: (Normal: )
Which of the following is the most appropriate next step in the evaluation or management of this patient?
- Perform an overnight -mg dexamethasone suppression testCevap
- BPrescribe levothyroxine to treat primary hypothyroidism
- CEstablish a diagnosis of polycystic ovary syndrome and initiate oral contraceptives
- DDiscontinue fluoxetine and initiate citalopram for mood control
- ERefer to oncology given a probability of adrenal malignancy