Soru

Zorluk: OrtaRheumatology and Immunology

Match each clinical presentation to the most likely associated rheumatologic condition.

  • A patient presenting with recurrent fetal loss, livedo reticularis, and a prolonged partial thromboplastin time (PTT) that fails to correct with normal plasma.Antiphospholipid syndrome
  • A patient presenting with progressive proximal muscle weakness, periorbital edema with a purplish hue, and erythematous papules on the knuckles.Dermatomyositis
  • A patient presenting with chronic lower back pain that improves with exercise, bilateral Achilles tendinitis, and acute unilateral anterior uveitis.Ankylosing spondylitis
  • A patient presenting with severe xerophthalmia, xerostomia, accelerated dental caries, and episodic bilateral parotid gland swelling.Sjögren syndrome
  • A patient presenting with daily spiking fevers, an evanescent salmon-colored maculopapular rash, and polyarthritis.Adult-onset Still disease

Cevap

1 matches Antiphospholipid syndrome, 2 matches Dermatomyositis, 3 matches Ankylosing spondylitis, 4 matches Sjögren syndrome, and 5 matches Adult-onset Still disease.
Each clinical vignette provides highly specific, pathognomonic features that unambiguously link to a single rheumatologic diagnosis.

Adım Adım Çözüm

1
Analyze the first presentation: recurrent fetal loss, livedo reticularis, and prolonged PTT without correction.
Identify Antiphospholipid syndrome.
These are classic clinical and laboratory manifestations of Antiphospholipid syndrome.
2
Analyze the second presentation: proximal muscle weakness, periorbital purplish edema, and knuckle papules.
Identify Dermatomyositis.
Proximal weakness paired with heliotrope rash and Gottron papules is pathognomonic for Dermatomyositis.
3
Analyze the third presentation: inflammatory back pain, Achilles tendinitis, and uveitis.
Identify Ankylosing spondylitis.
These symptoms describe a seronegative spondyloarthropathy with characteristic enthesitis and extraarticular manifestations.
4
Analyze the fourth presentation: sicca symptoms, dental caries, and parotid swelling.
Identify Sjögren syndrome.
These are the hallmark exocrine gland dysfunctions of Sjögren syndrome.
5
Analyze the fifth presentation: spiking fevers, salmon-colored rash, and polyarthritis.
Identify Adult-onset Still disease.
This triad is the classic presentation of Adult-onset Still disease.

Anahtar Kavram

Recognition of classic clinical and laboratory manifestations of major rheumatologic conditions.
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