A 64-year-old woman comes to the emergency department complaining of severe difficulty breathing that has progressively worsened over the last 72 hours. She also reports a persistent nighttime cough and states she must prop herself up with three pillows to sleep without feeling like she is suffocating. Her medical history includes hypertension, type 2 diabetes mellitus, and a 35-pack-year smoking history. Her temperature is 37.1°C (98.8°F), blood pressure is 162/94 mmHg, pulse is 108/min, and respirations are 24/min. Oxygen saturation is 92% on room air. Physical examination reveals distended neck veins when sitting at a 45-degree angle. Auscultation of the lungs demonstrates bibasilar crackles without wheezing. Cardiac auscultation reveals a regular rhythm, tachycardia, and a prominent S3 gallop. Examination of the lower extremities shows bilateral 2+ pitting edema extending to the mid-calves. Which of the following is the most appropriate initial pharmacological intervention for this patient?
- Intravenous furosemideCevap
- BInhaled albuterol and ipratropium
- CIntravenous methylprednisolone
- DOral levofloxacin
- EIntravenous ceftriaxone and azithromycin