Examkin

Soru

Zorluk: OrtaInfectious Disease Mechanisms

Match each patient's clinical presentation with the precise molecular mechanism of the responsible pathogen's primary virulence factor.

  • A 6-year-old unvaccinated boy presents with a thick, grayish pharyngeal pseudomembrane and severe cervical lymphadenopathy.Exotoxin-mediated ADP-ribosylation of elongation factor 2 (EF-2)
  • A 65-year-old woman develops profuse, watery, non-bloody diarrhea with a 'rice-water' appearance after consuming undercooked seafood.Exotoxin-mediated ADP-ribosylation of the Gs-alpha subunit
  • A 45-year-old man hospitalized for severe pneumonia develops cramping abdominal pain and frequent watery stools after a course of clindamycin.Exotoxin-mediated glycosylation of Rho-family GTPases
  • A 2-month-old infant presents with severe paroxysmal coughing spells followed by a high-pitched inspiratory whoop and post-tussive emesis.Exotoxin-mediated ADP-ribosylation of the Gi-alpha subunit
  • A 35-year-old landscaper presents with intense muscle spasms, trismus, and a rigid, arched back following a deep puncture wound to his foot.Exotoxin-mediated cleavage of SNARE proteins preventing inhibitory neurotransmitter release

Cevap

Diphtheria pairs with EF-2 ADP-ribosylation; Cholera pairs with Gs-alpha ADP-ribosylation; C. difficile pairs with Rho GTPase glycosylation; Pertussis pairs with Gi-alpha ADP-ribosylation; Tetanus pairs with SNARE protein cleavage.
Each correct pair accurately links a classic infectious disease presentation to the specific cellular mechanism of its causative exotoxin.

Adım Adım Çözüm

1
Analyze each clinical vignette to diagnose the infectious disease and identify the causative pathogen.
Diagnoses identified: 1. Diphtheria (C. diphtheriae), 2. Cholera (V. cholerae), 3. C. difficile colitis (C. difficile), 4. Pertussis (B. pertussis), 5. Tetanus (C. tetani).
Accurate pathogen identification is required to determine the specific virulence factors involved.
2
Recall the major exotoxin produced by each identified pathogen and its cellular target.
Diphtheria toxin targets EF-2; Cholera toxin targets Gs-alpha; C. difficile Toxin B targets Rho GTPases; Pertussis toxin targets Gi-alpha; Tetanospasmin targets SNARE proteins.
This establishes the link between the clinical syndrome and molecular mechanism.
3
Match the pathogen to the corresponding precise molecular mechanism provided in the options.
The accurate pairs are established based on the mechanism of action of each exotoxin.
Finalizing the pairings completes the matching exercise.

Anahtar Kavram

Bacterial Exotoxins and Cellular Mechanisms
Tahmini Süre:1m 30s
Bu soruyu puanla

Konular

Infectious Disease Mechanisms

Bu konudan daha fazla soru