A 38-year-old woman is evaluated in the ambulatory setting for recent, unexplained weight gain and new-onset hypertension. Over the past eight months, she has gained kg despite no changes to her diet or physical activity level. She also reports increasing difficulty climbing stairs and easy bruising on her extremities. Blood pressure is mmHg. Physical examination reveals facial plethora, prominent dorsocervical and supraclavicular fat pads, and broad violaceous striae across the lower abdomen. Initial screening for hypercortisolism is performed using a -mg overnight dexamethasone suppression test. Her serum cortisol level at 8:00 AM the following morning is (normal: ). Which of the following is the most appropriate next step in the diagnostic evaluation of this patient?
- Measurement of plasma adrenocorticotropic hormone (ACTH)Cevap
- BMagnetic resonance imaging (MRI) of the brain
- CHigh-dose (8-mg) dexamethasone suppression test
- DComputed tomography (CT) scan of the adrenal glands
- EBilateral inferior petrosal sinus sampling