Soru

Zorluk: OrtaInterpreting Laboratory Results

A 68-year-old woman is evaluated in the hospital for decreased urine output. She was admitted 2 days ago for severe gastroenteritis. Her past medical history is significant for hypertension treated with amlodipine. Her blood pressure is 98/60 mm Hg, and her pulse is 112/min. Mucous membranes are dry. Laboratory studies show the following:

TestResult
Serum sodium140 mEq/L
Serum potassium3.8 mEq/L
Serum chloride102 mEq/L
Blood urea nitrogen42 mg/dL
Serum creatinine2.0 mg/dL
Urine sodium14 mEq/L
Urine creatinine40 mg/dL

Based on the laboratory results provided, what is the patient's fractional excretion of sodium (FENa)? Give your answer as a percentage.

Cevap: 0.5 %

Cevap

0.5
The fractional excretion of sodium (FENa) evaluates the percentage of sodium filtered by the glomeruli that is eventually excreted in the urine. It is calculated using the formula: FENa=UNa×PCrPNa×UCr×100FENa = \frac{U_{Na} \times P_{Cr}}{P_{Na} \times U_{Cr}} \times 100. Plugging the patient's laboratory values into this formula yields 14×2.0140×40×100=285600×100=0.5%\frac{14 \times 2.0}{140 \times 40} \times 100 = \frac{28}{5600} \times 100 = 0.5\%. A FENa of less than 1% indicates a prerenal etiology for the patient's acute kidney injury, which is consistent with her history of severe gastroenteritis and clinical signs of profound volume depletion.

Adım Adım Çözüm

1
Identify the standard formula for fractional excretion of sodium.
FENa=UNa×PCrPNa×UCr×100FENa = \frac{U_{Na} \times P_{Cr}}{P_{Na} \times U_{Cr}} \times 100
This formula helps differentiate prerenal azotemia from intrinsic acute kidney injury by comparing sodium clearance to creatinine clearance.
2
Extract the specific serum and urine values from the clinical vignette.
UNa=14U_{Na} = 14, PNa=140P_{Na} = 140, UCr=40U_{Cr} = 40, PCr=2.0P_{Cr} = 2.0
Accurate identification of the variables is necessary for the subsequent mathematical calculation.
3
Calculate the ratio and multiply by 100 to find the percentage.
14×2.0140×40×100=285600×100=0.5%\frac{14 \times 2.0}{140 \times 40} \times 100 = \frac{28}{5600} \times 100 = 0.5\%
Completing the mathematical operation yields the final FENa value.

Anahtar Kavram

Calculating the fractional excretion of sodium (FENa) to determine the etiology of acute kidney injury.
Tahmini Süre:1m 0s
Bu soruyu puanla