A resident of a skilled nursing facility is transferred to the intensive care unit due to two days of progressive right upper quadrant pain, high fevers, and profound lethargy. Medical history is notable for severe ischemic cardiomyopathy with a left ventricular ejection fraction of 20%, as well as severe chronic obstructive pulmonary disease requiring home oxygen. On evaluation, blood pressure is 76/42 mm Hg, heart rate is 128/min, and temperature is 39.4°C (102.9°F). Physical examination reveals a rigid, exquisitely tender right subcostal region with localized guarding. Bedside ultrasonography demonstrates a distended gallbladder with an 8-mm thickened wall, significant pericholecystic fluid, and a large stone impacted in the infundibulum. Laboratory studies show a leukocyte count of 22,000/mm³ and an elevated serum lactate. The anesthesiology service determines the patient is currently a prohibitive risk for general anesthesia. Arrange the following management steps in the most appropriate chronological order for this patient's definitive care.
- 1Initiation of aggressive fluid resuscitation and broad-spectrum intravenous antimicrobials
- 2Image-guided percutaneous cholecystostomy tube insertion
- 3Medical optimization of cardiopulmonary comorbidities
- 4Antegrade cholangiography via the existing drainage tract
- 5Interval elective laparoscopic cholecystectomy