A public health clinic evaluates several patients presenting for routine screening or acute medical care. Hepatitis B virus (HBV) serological testing is performed. Match each laboratory testing profile to the most accurate clinical interpretation.
- HBsAg negative, Anti-HBs positive, Anti-HBc (total) negativeImmunity secondary to prior vaccination
- HBsAg negative, Anti-HBs positive, Anti-HBc (total) positiveImmunity secondary to resolved natural infection
- HBsAg positive, Anti-HBs negative, Anti-HBc (IgM) positiveAcute active infection
- HBsAg negative, Anti-HBs negative, Anti-HBc (IgM) positiveAcute infection in the window period
Cevap
The correct matching aligns HBsAg(-), Anti-HBs(+), Anti-HBc(total)(-) with vaccination immunity; HBsAg(-), Anti-HBs(+), Anti-HBc(total)(+) with natural infection immunity; HBsAg(+), Anti-HBs(-), Anti-HBc(IgM)(+) with acute infection; and HBsAg(-), Anti-HBs(-), Anti-HBc(IgM)(+) with the window period.
Each hepatitis B serological pattern represents a distinct clinical state. HBsAg is the hallmark of active infection, Anti-HBs represents immunity, and Anti-HBc indicates exposure to the native virus. By systematically evaluating these three markers, one can reliably establish the patient's immune and infectious status.
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Anahtar Kavram
Hepatitis B serology interpretation relies on understanding the sequence of antigen and antibody appearance. HBsAg indicates active infection, Anti-HBs indicates immunity, and Anti-HBc distinguishes between natural infection and vaccination.
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