Soru

A 71-year-old man is brought to the emergency department with a 3-day history of worsening shortness of breath, orthopnea, and palpitations. His past medical history is significant for heart failure with reduced ejection fraction, atrial fibrillation, and osteoarthritis. His maintenance medications include sacubitril-valsartan, carvedilol, apixaban, digoxin, and furosemide. He reports that 10 days ago, he developed a 'head cold' and a severe flare of his knee pain, for which he sought care at an urgent care clinic and purchased several over-the-counter products. During the medical history evaluation, the physician must identify any recent pharmacologic additions. Which of the following agents, if uncovered during the medication history, possess a direct pathophysiologic mechanism or drug-drug interaction that explains his acute clinical deterioration? (Select all that apply)