Soru

A 55-year-old female patient is hospitalized for the management of severe pneumonia complicated by sepsis. Her current body weight is $80 \text{ kg}$. The medical team decides to initiate therapy with an intravenous antimicrobial agent. This medication has a volume of distribution ($V_d$) of $0.5 \text{ L/kg}$ and follows first-order elimination kinetics with a half-life ($t_{1/2}$) of $6.93 \text{ hours}$. The drug is prescribed to be administered intermittently as an intravenous infusion every $12 \text{ hours}$. To achieve optimal bactericidal activity, the target average steady-state plasma concentration ($C_{ss,avg}$) is $10 \text{ mg/L}$. Assuming $100\%$ bioavailability for the intravenous route, what maintenance dose should be administered every $12 \text{ hours}$?