A 68-year-old man with progressive amyotrophic lateral sclerosis is brought to the emergency department by emergency medical services due to worsening shortness of breath and lethargy over the past 24 hours. On arrival, he is obtunded and responsive only to painful stimuli. Vital signs show a heart rate of 110/min, blood pressure of 145/90 mm Hg, and respiratory rate of 28/min. Oxygen saturation is 82% on room air, and arterial blood gas analysis reveals a pH of 7.18 and a PaCO2 of 85 mm Hg. The patient lacks decision-making capacity. His wife, who is his legally designated healthcare proxy, is present. The electronic medical record contains a valid advance directive completed by the patient three months ago when he had full capacity. The document explicitly states he does not want endotracheal intubation or invasive mechanical ventilation under any circumstances, but he wishes to receive non-invasive positive pressure ventilation for symptom relief. The wife is tearful and states, "I know what the form says, but he was depressed when he signed it. I cannot lose him today. You must intubate him."
Which of the following is the most appropriate next step in management?
- Initiate non-invasive positive pressure ventilation and decline the request for intubationCevap
- BProceed with endotracheal intubation as directed by the legally designated healthcare proxy
- CRequire a court order to determine the patient's legal competence at the time the directive was signed
- DWithhold all interventions and urgently consult the hospital ethics committee to resolve the conflict
- EAdminister high-dose intravenous lorazepam to alleviate respiratory distress while preparing for intubation