Question

Difficulty: MediumPharmacological Therapies

A client who is unresponsive following a traumatic brain injury is receiving continuous enteral feedings via a gastrostomy tube. The health care provider prescribes scheduled liquid oral phenytoin for seizure prophylaxis. The practical nurse is preparing to administer the medication. Which action should the nurse take?

  1. A
    Delegate the administration of the oral medication to an unlicensed assistive personnel while assessing the client's neurological status.
  2. B
    Calculate a reduced medication volume and administer it concurrently with the feeding formula to prevent gastrointestinal upset.
  3. Stop the continuous enteral feeding for 1 to 2 hours before administering the phenytoin dose.Answer
  4. D
    Draw up the liquid medication and administer it immediately without checking identifiers since the client cannot respond.

Answer

The correct action is to pause the continuous enteral feeding for 1 to 2 hours prior to administering the liquid phenytoin.
The correct action is to pause the continuous enteral feeding for 1 to 2 hours before administering the medication. Enteral feeding formulas significantly decrease the absorption of oral phenytoin in the gastrointestinal tract. If the feeding is not paused, the client may develop subtherapeutic phenytoin levels, increasing the risk of breakthrough seizures. The feeding should also remain paused for 1 to 2 hours after administration to allow for complete drug absorption.

Step-by-Step Solution

1
Review the prescribed medication and the client's current nutritional therapy.
The client is prescribed oral phenytoin and is receiving continuous enteral formula via a gastrostomy tube.
Identifying concurrent therapies is essential to prevent drug-nutrient interactions.
2
Analyze the specific interactions between phenytoin and enteral feeding formulas.
Enteral formulas contain proteins and calcium that bind to phenytoin in the gastrointestinal tract, significantly decreasing drug absorption.
Understanding the pharmacokinetic interaction guides the administration protocol.
3
Implement the necessary safety intervention for administration.
The continuous enteral feeding is stopped for 1 to 2 hours before the medication is given.
Pausing the feeding creates an empty stomach environment, ensuring maximum absorption of the phenytoin to maintain therapeutic seizure prophylaxis.

Key Concept

Phenytoin Administration with Enteral Feedings
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