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Difficulty: HardPharmacological Therapies

A school-aged child weighing 4444 lb is receiving care in an outpatient clinic for a severe skin infection. The healthcare provider prescribes clindamycin 2424 mg/kg/day orally, to be divided into equal doses administered every 88 hours. The clinic pharmacy dispenses clindamycin oral suspension at a concentration of 7575 mg/55 mL. How many mL should the practical nurse administer for a single dose? (Record answer to the nearest tenth. Do not include units in answer.)

Answer: 10.7 mL

Answer

10.7
To determine the correct administration volume, the practical nurse must first ensure the client's weight is in kilograms (4444 lb ÷2.2=20\div 2.2 = 20 kg). Next, the total daily dose is calculated by multiplying the weight by the prescribed rate (2020 kg ×24\times 24 mg/kg/day = 480480 mg/day). Because the prescription states the medication is to be administered every 88 hours, there are 33 administration times per day. The single dose amount is 480480 mg ÷3=160\div 3 = 160 mg/dose. Finally, using the desired over have formula multiplied by the vehicle (160160 mg ÷75\div 75 mg ×5\times 5 mL), the total volume per dose is calculated as 10.666...10.666... mL. Following standard rounding rules to the nearest tenth, the final answer is 10.710.7 mL.

Step-by-Step Solution

1
Convert the client's weight from pounds to kilograms.
2020 kg
Weight-based medication dosing requires the client's weight to be in kilograms. (4444 lb ÷2.2\div 2.2 lb/kg = 2020 kg)
2
Calculate the total daily dose of the prescribed medication.
480480 mg/day
The prescribed dosage rate is 2424 mg/kg/day. Multiply the client's weight by this rate: 2020 kg ×24\times 24 mg/kg = 480480 mg for the entire day.
3
Determine the amount of medication required for a single dose.
160160 mg/dose
The medication is ordered to be administered every 88 hours, which equates to 33 doses in a 2424-hour period (24÷8=324 \div 8 = 3). Divide the total daily dose by 33: 480480 mg ÷3\div 3 doses = 160160 mg per dose.
4
Calculate the liquid volume to administer using the available pharmacy concentration.
10.666...10.666... mL
Use the formula (Desired ÷\div Have) ×\times Vehicle. The desired dose is 160160 mg, the available strength is 7575 mg, and the vehicle volume is 55 mL. (160160 mg ÷75\div 75 mg) ×5\times 5 mL = 10.666...10.666... mL.
5
Round the calculated volume to the nearest tenth as instructed.
10.710.7 mL
The digit in the hundredths place is 66, which means you round the tenths digit up from 66 to 77, resulting in a final answer of 10.710.7.

Key Concept

Pediatric weight-based dosage calculation and liquid oral suspension conversion.
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Topics

Pharmacological Therapies

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