Question

Difficulty: MediumPharmacological Therapies

A practical nurse is preparing to administer a morning dose of 10 units of regular insulin and 20 units of NPH insulin subcutaneously to a client with type 2 diabetes mellitus. Arrange the following steps for preparing and mixing these insulins in the correct chronological order.

  1. 1Roll the NPH insulin vial gently between the palms of the hands.
  2. 2Inject 20 units of air into the NPH insulin vial and withdraw the needle.
  3. 3Inject 10 units of air into the regular insulin vial and keep the needle inserted.
  4. 4Invert the regular insulin vial and withdraw 10 units of regular insulin.
  5. 5Insert the needle into the NPH insulin vial and withdraw 20 units of NPH insulin.

Answer

The correct sequence is to roll the NPH vial, inject air into the NPH vial, inject air into the regular vial, withdraw the regular insulin, and finally withdraw the NPH insulin.
The standard 'clear before cloudy' procedure ensures that the shorter-acting, clear regular insulin is not contaminated by the longer-acting, cloudy NPH insulin. Rolling the NPH gently prevents bubble formation while ensuring the suspension is properly mixed. Injecting air into both vials prevents a vacuum from forming, which ensures accurate dosing.

Step-by-Step Solution

1
Roll the NPH insulin vial between the palms.
The cloudy insulin suspension is evenly mixed without forming bubbles.
Shaking the vial can cause bubbles, which leads to inaccurate dosing.
2
Inject 20 units of air into the NPH vial and remove the syringe.
Pressure is equalized in the NPH vial.
Air must be injected to prevent a vacuum, but withdrawing medication now would contaminate the needle before it enters the regular insulin vial.
3
Inject 10 units of air into the regular insulin vial.
Pressure is equalized in the regular insulin vial.
This prepares the regular insulin vial for immediate medication withdrawal.
4
Withdraw 10 units of regular insulin.
The short-acting (clear) insulin is drawn into the syringe first.
Drawing the clear insulin first prevents it from being contaminated by the longer-acting NPH insulin.
5
Withdraw 20 units of NPH insulin.
The syringe now contains a total of 30 units of mixed insulin.
Drawing the cloudy insulin last completes the mixture safely without risking contamination of the regular insulin vial.

Key Concept

Safe preparation and mixing of short-acting (clear) and intermediate-acting (cloudy) insulins.
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