Question

Difficulty: HardBiotechnology and Nanotechnology

With reference to the applications of nanotechnology in biomedicine and healthcare, consider the following statements:

1. Gold nanoparticles exhibit localized Surface Plasmon Resonance (SPR), enabling their usage in high-sensitivity optical biosensors and targeted photothermal cancer therapy.
2. Liposomes are solid metallic nanostructures engineered to permanently integrate into host genome sequences during targeted drug delivery.
3. Dendrimers are highly branched, spherical synthetic macromolecules possessing well-defined molecular architectures that allow precise encapsulation of therapeutic agents for controlled drug release.

Which of the statements given above is/are correct?

  1. 1 and 3 onlyAnswer
  2. B
    2 only
  3. C
    1 and 2 only
  4. D
    1, 2 and 3

Answer

1 and 3 only
The correct response identifies statements 1 and 3 as true while recognizing statement 2 as false. Gold nanoparticles utilize Surface Plasmon Resonance for diagnostics and hyperthermic tumor therapy, whereas dendrimers provide controlled drug loading due to their branched polymeric structure. Liposomes are lipid vesicles rather than metallic gene-altering particles.

Step-by-Step Solution

1
Evaluate Statement 1 regarding Gold Nanoparticles
Statement 1 is correct.
Gold nanoparticles undergo localized surface plasmon resonance (LSPR) when light interacts with conduction electrons on their surface, making them excellent candidates for biosensing, bio-imaging, and photothermal ablation of cancer cells.
2
Evaluate Statement 2 regarding Liposomes
Statement 2 is incorrect.
Liposomes are microscopic spherical vesicles composed of phospholipid bilayers surrounding an aqueous core. They are non-metallic lipid-based drug delivery vehicles and do not alter or integrate into host DNA.
3
Evaluate Statement 3 regarding Dendrimers
Statement 3 is correct.
Dendrimers are nanometer-scale, highly branched, 3D synthetic polymers with high functionality at their surface, ideal for drug encapsulation, targeted delivery, and gene therapy.

Key Concept

Nanomedicine and Nanobiotechnology Applications (Gold Nanoparticles, Liposomes, Dendrimers)
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