Question

Difficulty: MediumCell Biology, Genetics, and Evolution

In evolutionary cell biology, mitochondria and chloroplasts are classified as semi-autonomous organelles that originated through endosymbiotic events. Which of the following statements correctly describe the structural and genetic characteristics supporting their endosymbiotic evolutionary origin? (Select all correct options)

  1. Both organelles contain their own circular, double-stranded DNA molecules that are naked and devoid of extensive histone protein complexes, resembling bacterial genomes.Answer
  2. Both organelles contain 70S ribosomes within their internal compartments that are sensitive to antibacterial antibiotics such as chloramphenicol.Answer
  3. C
    Both organelles are fully autonomous and synthesize all their required enzymes and structural proteins independently of nuclear DNA.
  4. D
    Both organelles divide synchronously with the eukaryotic nucleus during the mitotic M phase through spindle fiber-mediated chromosomal segregation.

Answer

The statements highlighting circular histone-free DNA genomes and bacterial-type 70S ribosomes sensitive to antibiotics are correct.
The correct statements correctly identify the core molecular evidence supporting the Endosymbiotic Theory: mitochondria and chloroplasts maintain circular, histone-free DNA genomes analogous to prokaryotes, and possess 70S ribosomes whose protein synthesis is susceptible to bacterial antibiotic inhibitors.

Step-by-Step Solution

1
Analyze genomic organization of semi-autonomous organelles
Mitochondria and chloroplasts harbor prokaryotic-like circular DNA without histone proteins.
Endosymbiotic origin from ancestral alpha-proteobacteria and cyanobacteria preserved circular genome topology.
2
Evaluate translational machinery characteristics
Organellar ribosomes are 70S (composed of 50S and 30S subunits), inhibited by prokaryotic translation inhibitors like chloramphenicol.
Eukaryotic cytosolic ribosomes are 80S, demonstrating the distinct bacterial lineage of organellar translation systems.
3
Assess degree of genetic autonomy and division mechanism
Both organelles depend on imported nuclear proteins and divide independently by binary fission rather than mitotic spindle partitioning.
Endosymbiotic gene transfer to the host nucleus rendered these organelles semi-autonomous rather than completely autonomous.

Key Concept

Endosymbiotic Theory and Characteristics of Semi-Autonomous Organelles
Estimated Time:1m 15s
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