Question

Difficulty: MediumNeurosurgery

A 6868-year-old man presents to the emergency department complaining of severe, progressively worsening mid-back pain over the past 22 weeks. He has a history of advanced prostate cancer treated with androgen deprivation therapy. Over the past 2424 hours, he has developed difficulty walking and states his legs feel "heavy." He also reports an inability to urinate since early this morning. His temperature is 37.1∘C37.1^\circ\text{C} (98.8∘F98.8^\circ\text{F}), blood pressure is 142/88 mm Hg142/88\text{ mm Hg}, and pulse is 88/min88\text{/min}. On physical examination, there is exquisite point tenderness to palpation over the T10 spinous process. Neurologic examination reveals 3/53/5 motor strength in the lower extremities bilaterally. There is decreased sensation to pinprick and temperature below the umbilicus. Deep tendon reflexes are 3+3+ at the patellae and ankles, with bilateral upgoing plantar responses. Post-void residual ultrasound shows 550 mL550\text{ mL} of urine in the bladder. Which of the following is the most appropriate initial step in the management of this patient?

  1. A
    Magnetic resonance imaging of the spine
  2. B
    Intravenous broad-spectrum antibiotics
  3. Intravenous dexamethasoneAnswer
  4. D
    Urgent decompressive laminectomy
  5. E
    Lumbar puncture

Answer

Intravenous dexamethasone
This patient's presentation of back pain, lower extremity weakness, sensory level at T10, upper motor neuron signs (hyperreflexia, positive Babinski), and autonomic dysfunction (urinary retention) in the setting of advanced prostate cancer is highly concerning for malignant epidural spinal cord compression (MESCC). When MESCC is clinically suspected, the most critical initial step is the immediate administration of high-dose intravenous corticosteroids, such as dexamethasone. This intervention effectively decreases peritumoral vasogenic edema, thereby relieving pressure on the spinal cord and helping to preserve or restore neurologic function. Corticosteroids should be given empirically as soon as the diagnosis is suspected and must not be delayed by the time required to arrange and perform diagnostic imaging.

Step-by-Step Solution

1
Analyze the patient's presentation and history.
The patient has progressive back pain, paraparesis, a T10 sensory level, upper motor neuron signs, and urinary retention, in the setting of advanced prostate cancer.
Identifying the clinical syndrome points directly to acute spinal cord compression, most likely secondary to epidural metastasis.
2
Determine the prioritized management sequence for malignant epidural spinal cord compression.
The standard sequence is immediate medical stabilization with corticosteroids followed by diagnostic imaging.
Corticosteroids reduce peritumoral vasogenic edema and protect the spinal cord from irreversible damage while awaiting definitive imaging and treatment.
3
Select the correct initial intervention.
Intravenous dexamethasone is chosen as the first step.
It must be given immediately upon clinical suspicion, prior to obtaining an MRI.

Key Concept

In patients with suspected malignant epidural spinal cord compression, the initial step in management is the immediate administration of high-dose intravenous corticosteroids, before obtaining confirmatory magnetic resonance imaging.
Estimated Time:1m 15s
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