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Difficulty: EasyHematology and Oncology

Match each classic peripheral blood smear finding to the hematologic disorder with which it is most characteristically associated.

  • Bite cells and Heinz bodiesGlucose-6-phosphate dehydrogenase (G6PD) deficiency
  • Hypersegmented neutrophilsVitamin B12 deficiency
  • Auer rodsAcute myeloid leukemia (AML)
  • Smudge cellsChronic lymphocytic leukemia (CLL)
  • SchistocytesThrombotic thrombocytopenic purpura (TTP)

Answer

The correct pairings connect hallmark morphologic features on the peripheral smear to their underlying pathophysiology: Bite cells/Heinz bodies with G6PD deficiency, Hypersegmented neutrophils with Vitamin B12 deficiency, Auer rods with AML, Smudge cells with CLL, and Schistocytes with TTP.
Each classic peripheral blood smear finding directly represents the underlying pathophysiology of its respective hematologic disorder, testing foundational clinical knowledge required for accurate diagnosis.

Step-by-Step Solution

1
Analyze the peripheral smear finding for 'Bite cells and Heinz bodies'.
Matched with G6PD deficiency.
These indicate oxidative damage to red blood cells, the core mechanism of G6PD deficiency.
2
Analyze 'Hypersegmented neutrophils'.
Matched with Vitamin B12 deficiency.
Hypersegmentation is a hallmark of impaired DNA synthesis and megaloblastic anemias.
3
Analyze 'Auer rods'.
Matched with Acute myeloid leukemia (AML).
Auer rods are the pathognomonic finding in immature myeloblasts.
4
Analyze 'Smudge cells'.
Matched with Chronic lymphocytic leukemia (CLL).
Fragile lymphocytes are easily ruptured during the physical smearing process in CLL.
5
Analyze 'Schistocytes'.
Matched with Thrombotic thrombocytopenic purpura (TTP).
Fragmented red blood cells are the hallmark of intravascular shearing in microangiopathic hemolytic anemias.

Key Concept

Peripheral blood smear interpretation in hematologic disorders
Estimated Time:1m 0s
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Topics

Hematology and Oncology

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