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Difficulty: EasyRheumatology and Immunology

Match each specific autoantibody profile with its most strongly associated rheumatologic condition.

  • Anti-double-stranded DNA (anti-dsDNA)Systemic lupus erythematosus (SLE)
  • Anti-centromere antibodyLimited cutaneous systemic sclerosis
  • Anti-Jo-1 antibodyPolymyositis / Dermatomyositis
  • Anti-cyclic citrullinated peptide (anti-CCP)Rheumatoid arthritis

Answer

The correct pairings are: Anti-dsDNA matches with Systemic lupus erythematosus (SLE); Anti-centromere matches with Limited cutaneous systemic sclerosis; Anti-Jo-1 matches with Polymyositis / Dermatomyositis; Anti-CCP matches with Rheumatoid arthritis.
Each autoantibody listed has a distinct, classic disease association commonly tested on the USMLE. Anti-dsDNA is specific for SLE, anti-centromere for limited systemic sclerosis, anti-Jo-1 for inflammatory myopathies, and anti-CCP for rheumatoid arthritis. Recognizing these fundamental associations is essential for diagnosing systemic autoimmune disorders.

Step-by-Step Solution

1
Identify the target disease for anti-dsDNA.
Systemic lupus erythematosus (SLE).
Anti-dsDNA is a classic, highly specific diagnostic marker for SLE.
2
Identify the target disease for anti-centromere antibodies.
Limited cutaneous systemic sclerosis.
This antibody is uniquely linked to the limited cutaneous subtype of scleroderma.
3
Identify the target disease for anti-Jo-1 antibodies.
Polymyositis / Dermatomyositis.
Anti-Jo-1 targets histidyl-tRNA synthetase and is classically seen in these inflammatory myopathies.
4
Identify the target disease for anti-CCP.
Rheumatoid arthritis.
Anti-CCP is the most specific serologic test available for diagnosing rheumatoid arthritis.

Key Concept

Serologic autoantibody profiles in specific rheumatologic diseases
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Topics

Rheumatology and Immunology

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