Question

Difficulty: HardHematology and Oncology

While rounding in the surgical intensive care unit, a physician is urgently called to the bedside of a 68-year-old male patient who abruptly developed respiratory distress. The patient underwent a right hemicolectomy for stage III colon cancer two days ago. Two hours prior to the acute event, his hemoglobin level was noted to be 6.86.8 g/dL, prompting the initiation of a cross-matched packed red blood cell transfusion. Approximately 3030 minutes after the transfusion began, the patient reported the sudden onset of shaking chills and severe pain in his right flank.

Vital signs reveal a temperature of 39.2∘C39.2^\circ\text{C} (102.6∘F102.6^\circ\text{F}), heart rate of 122/min122/\text{min}, blood pressure of 85/5085/50 mm Hg, and respiratory rate of 24/min24/\text{min}. Pulse oximetry shows an oxygen saturation of 94%94\% on room air.

Physical examination shows profound diaphoresis and anxiety. Jugular venous pulsations are not elevated. Auscultation of the chest reveals clear breath sounds in all lung fields. The surgical incision is intact without erythema or purulent drainage. Inspection of the Foley catheter drainage system reveals that the previously clear, yellow urine has acutely transitioned to a dark, reddish-brown color.

Which of the following is the most appropriate initial step in management?

  1. Stop the transfusion and administer copious intravenous normal salineAnswer
  2. B
    Stop the transfusion and administer intravenous furosemide
  3. C
    Stop the transfusion and administer intravenous broad-spectrum antibiotics
  4. D
    Continue the transfusion and administer intravenous acetaminophen and diphenhydramine
  5. E
    Stop the transfusion and transport the patient for computed tomography pulmonary angiography

Answer

The most appropriate initial step is to stop the transfusion and administer copious intravenous normal saline.
The correct answer is to stop the transfusion and administer copious intravenous normal saline. This patient's presentation of sudden chills, fever, severe flank pain, hypotension, and dark reddish-brown urine (hemoglobinuria) shortly after starting a blood transfusion is the classic triad for an Acute Hemolytic Transfusion Reaction (AHTR). AHTR is a life-threatening complication most commonly caused by ABO incompatibility resulting from a clerical error. The rapid destruction of donor erythrocytes by preformed host antibodies releases large amounts of free hemoglobin into the plasma. This hemoglobin is filtered by the kidneys, where it can precipitate and cause acute tubular necrosis, leading to oliguric renal failure. The initial, most critical management of AHTR is to immediately halt the offending transfusion to limit further hemolysis, and to provide aggressive volume resuscitation with intravenous normal saline. Copious hydration induces a diuresis that flushes the kidneys, preventing hemoglobin precipitation and mitigating hypotensive shock.

Step-by-Step Solution

1
Analyze the patient's acute symptom onset in relation to the medical intervention.
The patient developed fever, hypotension, severe flank pain, and gross hemoglobinuria precisely 30 minutes after initiating a packed red blood cell transfusion.
Establishing the temporal relationship of symptoms to the transfusion is critical for identifying a transfusion reaction.
2
Differentiate the type of transfusion reaction based on the classic clinical triad.
The combination of fever, flank pain, and reddish-brown urine (hemoglobinuria) accompanied by hemodynamic instability is highly specific for an Acute Hemolytic Transfusion Reaction (AHTR).
This specific presentation rules out other complications like TACO (which presents with hypertension and pulmonary edema) and TRALI (which lacks hemoglobinuria and flank pain).
3
Determine the most critical immediate intervention to prevent morbidity and mortality.
The immediate action is to halt the infusion of incompatible blood and initiate aggressive intravenous hydration with normal saline.
Aggressive volume resuscitation maintains urine output, preventing the precipitation of released hemoglobin in the renal tubules and averting acute tubular necrosis (ATN).

Key Concept

Acute Hemolytic Transfusion Reaction (AHTR) classically presents with fever, flank pain, hemoglobinuria, and hypotension shortly after beginning a blood transfusion; immediate management requires stopping the transfusion and providing aggressive intravenous normal saline to prevent acute tubular necrosis.
Estimated Time:1m 30s
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