Question

Difficulty: MediumNeurosurgery

A 22-year-old male is transported to the trauma bay via helicopter following a high-speed motorcycle collision where he was ejected and found without a helmet. Upon arrival, his blood pressure is 165/95 mm Hg, and his heart rate is 55/min. He does not open his eyes to pain, makes incomprehensible sounds, and exhibits extension of his arms and legs in response to painful stimuli. Examination reveals a 6-mm, nonreactive right pupil and a 3-mm, briskly reactive left pupil.

Arrange the following management steps in the most appropriate chronological order for this patient.

  1. 1Perform endotracheal intubation with in-line cervical spine stabilization
  2. 2Administer an intravenous hyperosmolar agent
  3. 3Obtain an urgent noncontrast head computed tomography (CT) scan
  4. 4Transfer to the operating room for decompressive craniotomy

Answer

The correct sequence is: 1) Perform endotracheal intubation, 2) Administer an intravenous hyperosmolar agent, 3) Obtain a noncontrast head CT scan, 4) Transfer to the operating room for decompressive craniotomy.
The management of a severe traumatic brain injury with signs of impending herniation follows a strict, sequential algorithm prioritizing the airway, temporization of intracranial pressure (ICP), and definitive diagnosis followed by surgical treatment. The patient has a GCS of 5 (Eyes 1, Verbal 2, Motor 2), Cushing reflex (hypertension and bradycardia), and an asymmetric, unreactive pupil (indicating right uncal herniation). The first priority is securing the airway via endotracheal intubation with cervical spine precautions, as a GCS < 8 indicates an inability to protect the airway. Next, because there are overt clinical signs of herniation, empirical medical therapy to lower ICP (such as intravenous mannitol or hypertonic saline) must be administered immediately. This should not be delayed for imaging. After these temporizing measures are initiated, a noncontrast CT scan of the head is obtained to identify the underlying pathology (e.g., epidural or subdural hematoma). Finally, based on the imaging findings, the patient is taken to the operating room for definitive surgical decompression.

Step-by-Step Solution

1
Assess the Glasgow Coma Scale (GCS) and airway stability.
GCS is calculated as 5 (Eyes 1, Verbal 2, Motor 2). This necessitates immediate endotracheal intubation.
Airway protection takes absolute precedence in trauma patients, especially to prevent secondary ischemic brain injury from hypoxia.
2
Recognize signs of impending brain herniation and intervene medically.
Identify uncal herniation (dilated right pupil, decerebrate posturing) and administer intravenous mannitol or hypertonic saline.
Clinical signs of herniation require immediate temporizing medical therapy to reduce intracranial pressure prior to obtaining imaging.
3
Acquire diagnostic neuroimaging.
Perform a noncontrast CT scan of the head.
Imaging is required to differentiate between types of intracranial hemorrhage and pinpoint the location for the neurosurgeon.
4
Provide definitive neurosurgical treatment.
Transfer the patient to the operating room.
Surgical decompression is the ultimate treatment to relieve the mass effect and prevent fatal brainstem compression.

Key Concept

Management algorithm for severe traumatic brain injury with impending brain herniation
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