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Difficulty: MediumRheumatology and Immunology

Match each autoantibody profile to the rheumatologic condition with which it is most specifically associated.

  • Anti-Scl-70 (anti-topoisomerase I) antibodiesDiffuse cutaneous systemic sclerosis
  • Anti-Jo-1 (anti-histidyl-tRNA synthetase) antibodiesPolymyositis / Dermatomyositis
  • Anti-U1 ribonucleoprotein (anti-U1 RNP) antibodiesMixed connective tissue disease
  • Anti-cyclic citrullinated peptide (anti-CCP) antibodiesRheumatoid arthritis

Answer

Anti-Scl-70 pairs with Diffuse cutaneous systemic sclerosis; Anti-Jo-1 pairs with Polymyositis / Dermatomyositis; Anti-U1 RNP pairs with Mixed connective tissue disease; Anti-CCP pairs with Rheumatoid arthritis.
Each autoantibody has a distinct clinical association that aids in differentiating various rheumatologic diseases. Anti-Scl-70 is linked to diffuse systemic sclerosis. Anti-Jo-1 is tied to inflammatory myopathies (polymyositis/dermatomyositis). Anti-U1 RNP defines mixed connective tissue disease. Anti-CCP is a highly specific marker for rheumatoid arthritis.

Step-by-Step Solution

1
Analyze the first antibody, Anti-Scl-70.
It pairs with diffuse cutaneous systemic sclerosis.
Anti-Scl-70 (anti-topoisomerase I) is a classic marker for the diffuse variant of systemic sclerosis.
2
Analyze the second antibody, Anti-Jo-1.
It pairs with polymyositis / dermatomyositis.
Anti-Jo-1 is an anti-synthetase antibody strongly associated with inflammatory myopathies.
3
Analyze the third antibody, Anti-U1 RNP.
It pairs with mixed connective tissue disease.
The defining serologic feature of mixed connective tissue disease is the presence of high-titer anti-U1 RNP antibodies.
4
Analyze the fourth antibody, Anti-CCP.
It pairs with rheumatoid arthritis.
Anti-CCP antibodies have very high specificity for rheumatoid arthritis and often appear before clinical symptoms.

Key Concept

Specific autoantibody profiles in rheumatologic conditions
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Topics

Rheumatology and Immunology

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