Identify the classic autoantibody marker most strongly associated with each of the following clinical diagnoses.
- Primary biliary cholangitisAnti-mitochondrial antibodies
- Autoimmune hepatitisAnti-smooth muscle antibodies
- Primary sclerosing cholangitisPerinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA)
- Celiac diseaseAnti-tissue transglutaminase IgA antibodies
Answer
Primary biliary cholangitis matches with Anti-mitochondrial antibodies, Autoimmune hepatitis with Anti-smooth muscle antibodies, Primary sclerosing cholangitis with p-ANCA, and Celiac disease with Anti-tissue transglutaminase IgA.
Each of the listed immune-mediated conditions has a distinct, high-yield serologic profile required for board examinations. Primary biliary cholangitis is famously associated with anti-mitochondrial antibodies. Autoimmune hepatitis (Type 1) features anti-smooth muscle antibodies. Primary sclerosing cholangitis, which has a strong link to inflammatory bowel disease, is associated with perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA). Finally, Celiac disease relies on anti-tissue transglutaminase IgA antibodies for initial serologic screening.
Step-by-Step Solution
Key Concept
Autoimmune and serologic markers in gastroenterology and hepatology