Examkin

Question

Difficulty: EasyRheumatology and Immunology

Autoantibody testing plays a critical role in the diagnosis and classification of connective tissue diseases. Match each specific autoantibody profile to the rheumatologic condition it is most strongly associated with.

  • Anti-cyclic citrullinated peptide (anti-CCP)Rheumatoid arthritis
  • Anti-double-stranded DNA (anti-dsDNA)Systemic lupus erythematosus
  • Anti-centromereLimited cutaneous systemic sclerosis
  • Anti-Jo-1 (histidyl-tRNA synthetase)Polymyositis / Dermatomyositis

Answer

Anti-CCP matches with Rheumatoid arthritis; Anti-dsDNA matches with Systemic lupus erythematosus; Anti-centromere matches with Limited cutaneous systemic sclerosis; Anti-Jo-1 matches with Polymyositis / Dermatomyositis.
The correct matches represent foundational, high-yield serologic associations required for diagnosing classic rheumatologic conditions. Each autoantibody serves as a highly specific diagnostic criterion for its respective connective tissue disease.

Step-by-Step Solution

1
Identify the primary disease association for anti-CCP antibodies.
Matches with rheumatoid arthritis.
Anti-CCP is the most specific marker for rheumatoid arthritis.
2
Identify the primary disease association for anti-dsDNA antibodies.
Matches with systemic lupus erythematosus.
Anti-dsDNA is highly specific for SLE and correlates with renal involvement.
3
Identify the primary disease association for anti-centromere antibodies.
Matches with limited cutaneous systemic sclerosis.
This is the classic marker for limited SSc (CREST syndrome), distinguishing it from diffuse SSc which is associated with anti-Scl-70.
4
Identify the primary disease association for anti-Jo-1 antibodies.
Matches with polymyositis / dermatomyositis.
Anti-Jo-1 is an antisynthetase antibody characteristic of inflammatory myopathies.

Key Concept

Foundational Serologic Markers in Rheumatologic Diseases
Rate this question

Topics

Rheumatology and Immunology

More questions from this topic