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Difficulty: EasyRheumatology and Immunology

Match each of the following highly specific autoantibodies to the rheumatologic condition with which they are most classically associated.

  • Anti-double-stranded DNA (Anti-dsDNA)Systemic Lupus Erythematosus (SLE)
  • Anti-centromereLimited Cutaneous Systemic Sclerosis (CREST syndrome)
  • Anti-cyclic citrullinated peptide (Anti-CCP)Rheumatoid Arthritis
  • Anti-Ro/SSASjögren Syndrome

Answer

Anti-dsDNA matches with Systemic Lupus Erythematosus; Anti-centromere matches with Limited Cutaneous Systemic Sclerosis; Anti-CCP matches with Rheumatoid Arthritis; Anti-Ro/SSA matches with Sjögren Syndrome.
Each listed autoantibody serves as a highly specific diagnostic marker for a classic rheumatologic condition. Anti-dsDNA confirms SLE. Anti-centromere confirms Limited Cutaneous Systemic Sclerosis. Anti-CCP confirms Rheumatoid Arthritis. Anti-Ro/SSA strongly supports a diagnosis of Sjögren Syndrome.

Step-by-Step Solution

1
Evaluate the clinical association for Anti-dsDNA.
Anti-dsDNA is specific for Systemic Lupus Erythematosus.
This is a core diagnostic criterion for SLE that also helps monitor disease flares.
2
Evaluate the clinical association for Anti-centromere.
Anti-centromere is specific for Limited Cutaneous Systemic Sclerosis.
It distinguishes limited cutaneous disease from diffuse cutaneous systemic sclerosis, which is typically associated with anti-Scl-70.
3
Evaluate the clinical association for Anti-CCP.
Anti-CCP is specific for Rheumatoid Arthritis.
It is more specific than Rheumatoid Factor (RF) and serves as a strong prognostic marker for erosive disease.
4
Evaluate the clinical association for Anti-Ro/SSA.
Anti-Ro/SSA is specific for Sjögren Syndrome.
These antibodies are the primary serologic markers used to support a diagnosis of primary Sjögren Syndrome.

Key Concept

Autoantibody specificities in rheumatologic diseases
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Topics

Rheumatology and Immunology

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