Question

Difficulty: EasyDepressive Disorders

Match each patient's clinical presentation with the most appropriate primary or adjunctive treatment modality.

  • A 75-year-old man with severe depressed mood, psychotic features, and life-threatening refusal to eat or drink.Electroconvulsive therapy (ECT)
  • A 24-year-old woman presenting with severe depression who reports a past episode of decreased need for sleep, rapid speech, and grandiosity.Quetiapine
  • A 32-year-old man with a first episode of moderate major depressive disorder without psychotic features or prior psychiatric history.Selective serotonin reuptake inhibitor (SSRI)
  • A 45-year-old woman with a history of depressive episodes that consistently begin in November and resolve by April.Bright light therapy

Answer

The correct matches align the psychotic/food-refusing patient with ECT, the bipolar depression patient with quetiapine, the uncomplicated MDD patient with an SSRI, and the seasonal pattern patient with bright light therapy.
Each treatment is matched to its classic indication: ECT for rapid response in psychotic or life-threatening depression; quetiapine for bipolar depression to avoid SSRI-induced mania; SSRIs for standard major depression; and light therapy for seasonal pattern.

Step-by-Step Solution

1
Analyze the 75-year-old man's presentation.
Severe depression with psychotic features and food refusal.
Requires the most rapid and effective intervention available, which is ECT.
2
Analyze the 24-year-old woman's presentation.
Depression with a history of mania (elevated mood, decreased sleep, grandiosity).
Indicates bipolar depression, requiring a medication with mood-stabilizing properties (like quetiapine) while avoiding SSRI monotherapy.
3
Analyze the 32-year-old man's presentation.
Uncomplicated, first-episode moderate major depressive disorder.
Warrants standard first-line pharmacotherapy with an SSRI.
4
Analyze the 45-year-old woman's presentation.
Depressive episodes strictly tied to fall and winter months.
Meets criteria for seasonal pattern, making bright light therapy a primary indication.

Key Concept

Selecting appropriate first-line and specialized treatments for various depressive presentations, including recognizing bipolar depression.
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