Question

Difficulty: Very hardOrthopedic Surgery

A 42-year-old woman is brought to the emergency department after tripping over a rug and falling onto her right arm. She reports severe, sharp pain and an inability to move her right arm. Vital signs are within normal limits. Physical examination reveals an obvious deformity and significant swelling over the middle-to-distal aspect of the right arm. Upon initial neurologic evaluation, the patient has full active extension of the right wrist and fingers, and sensation is intact to light touch over the dorsum of the hand. Radial and ulnar pulses are 2+ and capillary refill is less than 2 seconds. Radiographs of the right upper extremity demonstrate a displaced, spiral fracture of the distal third of the humeral shaft. An orthopedic surgery resident performs a closed reduction in the emergency department, and a coaptation splint is applied. Post-reduction radiographs confirm acceptable alignment of the fracture fragments. Thirty minutes later, during a routine neurovascular reassessment, the patient is unable to actively extend her right wrist or digits. Sensation to light touch is now decreased over the dorsal web space between the thumb and index finger. Distal pulses remain 2+. Which of the following is the most appropriate next step in management?

  1. Surgical exploration of the radial nerve and internal fixation of the fractureAnswer
  2. B
    Continuation of the splint and transition to a functional fracture brace in 1 to 2 weeks
  3. C
    Immediate removal of the splint and repeat closed reduction of the fracture
  4. D
    Urgent computed tomography angiography of the right upper extremity
  5. E
    Electromyography and nerve conduction studies of the right upper extremity

Answer

Surgical exploration of the radial nerve and internal fixation of the fracture
The correct response is surgical exploration of the radial nerve and internal fixation. This vignette highlights a high-yield, critical exception to a general orthopedic rule. The radial nerve runs directly along the posterior aspect of the humerus in the spiral groove, making it highly susceptible to injury in mid-shaft and distal-third (Holstein-Lewis) humeral fractures. If a patient presents with a radial nerve palsy initially (primary palsy), the standard of care is closed reduction, splinting/bracing, and observation, because up to 90% of these neurapraxic injuries resolve spontaneously within 3 to 4 months. However, this patient had a normal neurological examination initially and developed the palsy only AFTER closed reduction. A new-onset (secondary or iatrogenic) nerve palsy following manipulation strongly indicates that the radial nerve has become physically trapped between the fracture fragments. This entrapment causes acute ischemia to the nerve. Leaving the nerve trapped will lead to permanent, irreversible nerve damage. Therefore, a secondary nerve palsy is an absolute indication for immediate surgical exploration to release the nerve, followed by open reduction and internal fixation (ORIF) of the bone.

Step-by-Step Solution

1
Analyze the initial presentation
The patient has a distal third humeral shaft fracture with an initially intact radial nerve (normal wrist/finger extension and dorsal hand sensation).
Establishing the baseline neurological status is critical for identifying iatrogenic complications during fracture management.
2
Evaluate the post-intervention clinical change
Following closed reduction and splinting, the patient develops a new-onset radial nerve palsy (wrist drop, loss of finger extension, sensory deficit in the first dorsal web space).
A change in neurological status following manipulation changes the diagnostic and therapeutic algorithm completely.
3
Determine the indication for surgery based on the timeline of the nerve palsy
Because the radial nerve palsy is secondary (occurred after reduction), it indicates nerve entrapment in the fracture site, necessitating immediate surgical exploration.
Primary radial nerve palsies are observed, but secondary (iatrogenic) radial nerve palsies require urgent operative intervention to free the nerve and fix the fracture.

Key Concept

Secondary (iatrogenic) radial nerve palsy following closed reduction of a humeral shaft fracture is a surgical emergency indicating nerve entrapment, requiring immediate open exploration and internal fixation.
Estimated Time:2m 0s
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