Match each patient's clinical presentation with the autoantibody most specific to or characteristic of their underlying diagnosis.
- A 32-year-old woman with recurrent second-trimester miscarriages, a new left lower extremity deep vein thrombosis, and an isolated prolonged partial thromboplastin time.Anticardiolipin antibodies
- A 45-year-old woman with chronic fatigue, difficulty swallowing solid foods, thickened skin confined to her fingers and face, and severe episodic digital pallor in cold weather.Anti-centromere antibodies
- A 55-year-old woman with progressive difficulty standing from a seated position, an erythematous periorbital rash, and violaceous, scaling papules over her metacarpophalangeal joints.Anti-Jo-1 antibodies
- A 40-year-old woman with a chronic sensation of 'sand in the eyes,' the need to drink water to swallow dry foods, and bilateral parotid gland enlargement.Anti-Ro/SSA antibodies
- A 28-year-old woman with a photosensitive facial rash sparing the nasolabial folds, pleuritic chest pain, diffuse joint aches, and new-onset proteinuria.Anti-double-stranded DNA (anti-dsDNA) antibodies
Answer
The clinical vignettes match as follows: Antiphospholipid syndrome with Anticardiolipin antibodies, Limited cutaneous systemic sclerosis with Anti-centromere antibodies, Dermatomyositis with Anti-Jo-1 antibodies, Sjögren syndrome with Anti-Ro/SSA antibodies, and Systemic Lupus Erythematosus with Anti-double-stranded DNA antibodies.
Each autoantibody represents a highly specific serologic marker for the respective clinical syndrome, confirming the diagnosis based on the classic physical and historical findings provided in the vignettes.
Step-by-Step Solution
Key Concept
Serologic markers and autoantibody profiles of systemic autoimmune and rheumatologic diseases.