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Difficulty: EasyRheumatology and Immunology

A medical student is reviewing serologic markers for various autoimmune diseases. Match each specific autoantibody below to the rheumatologic condition with which it is most strongly associated.

  • Anti-cyclic citrullinated peptide (anti-CCP)Rheumatoid arthritis
  • Anti-double-stranded DNA (anti-dsDNA)Systemic lupus erythematosus (SLE)
  • Anti-centromere antibodyLimited cutaneous systemic sclerosis
  • Anti-Ro/SSA antibodySjögren syndrome

Answer

Anti-CCP matches with Rheumatoid arthritis; Anti-dsDNA matches with Systemic lupus erythematosus (SLE); Anti-centromere matches with Limited cutaneous systemic sclerosis; Anti-Ro/SSA matches with Sjögren syndrome.
Each autoantibody serves as a specific diagnostic marker for a distinct rheumatologic condition. Anti-CCP is specific for rheumatoid arthritis, anti-dsDNA for SLE, anti-centromere for limited cutaneous systemic sclerosis, and anti-Ro/SSA for Sjögren syndrome.

Step-by-Step Solution

1
Identify the disease association for anti-CCP.
Anti-CCP is linked to Rheumatoid arthritis.
It is a highly specific marker for RA that helps differentiate it from other inflammatory arthritides.
2
Identify the disease association for anti-dsDNA.
Anti-dsDNA is linked to Systemic lupus erythematosus (SLE).
It is a specific marker for SLE that often fluctuates with disease flares.
3
Identify the disease association for anti-centromere.
Anti-centromere is linked to Limited cutaneous systemic sclerosis.
It is the primary autoantibody found in patients with the limited form of systemic sclerosis.
4
Identify the disease association for anti-Ro/SSA.
Anti-Ro/SSA is linked to Sjögren syndrome.
It is frequently tested during the diagnostic workup for sicca symptoms characteristic of Sjögren syndrome.

Key Concept

Autoantibody profiles are essential in the diagnosis and classification of rheumatologic diseases.
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Topics

Rheumatology and Immunology

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