A 48-year-old female presents to the emergency department with severe, constant epigastric pain that radiates to her mid-back. The pain began 12 hours ago and has been accompanied by multiple episodes of non-bilious emesis. She denies alcohol consumption, recent travel, or new medications.
Vital signs:
- Temperature: 38.2°C (100.8°F)
- Blood pressure: 112/68 mmHg
- Heart rate: 118/min
- Respiratory rate: 22/min
Physical examination reveals a distressed patient with severe epigastric tenderness to deep palpation, without guarding or rebound. Bowel sounds are hypoactive.
Laboratory results:
| Leukocyte count | |
| Lipase | |
| Total bilirubin | |
| Aspartate aminotransferase (AST) | |
| Alanine aminotransferase (ALT) | |
| Thyroid-stimulating hormone (TSH) | (Normal: 0.5–5.0) |
| Free T4 | (Normal: 0.9–1.7) |
Arterial blood gas (room air):
| pH | |
| | |
| | |
An abdominal ultrasound demonstrates multiple echogenic foci within the gallbladder lumen with posterior acoustic shadowing. The common bile duct measures 4 mm in diameter, and the gallbladder wall is 2 mm thick without pericholecystic fluid. The pancreas is partially obscured by overlying bowel gas.
Which of the following is the most appropriate next step in the management of this patient?
- AIntravenous sodium bicarbonate infusion
- BEmpiric administration of intravenous meropenem
- Aggressive hydration with isotonic crystalloidsAnswer
- DInitiation of methimazole therapy
- EUrgent endoscopic retrograde cholangiopancreatography