Question

Difficulty: HardInterpreting Laboratory Results

A 27-year-old woman with a history of type 1 diabetes mellitus presents to the emergency department with abdominal pain, nausea, and severe, intractable vomiting for the past 48 hours. She stopped taking her insulin yesterday due to an inability to tolerate oral intake. On physical examination, her pulse is 118/min, blood pressure is 98/60 mm Hg, and respiratory rate is 18/min. Her mucous membranes are dry.

Arterial blood gas on room air reveals:
pH: 7.387.38
pCO2pCO_2: 42 mm Hg42 \text{ mm Hg}

Serum laboratory results are as follows:
Sodium: 140 mEq/L140 \text{ mEq/L}
Potassium: 3.1 mEq/L3.1 \text{ mEq/L}
Chloride: 88 mEq/L88 \text{ mEq/L}
Bicarbonate: 24 mEq/L24 \text{ mEq/L}
Glucose: 610 mg/dL610 \text{ mg/dL}
Blood urea nitrogen: 42 mg/dL42 \text{ mg/dL}
Creatinine: 1.8 mg/dL1.8 \text{ mg/dL}

To evaluate for the presence of a mixed acid-base disorder, the physician calculates the delta-adjusted bicarbonate (also known as the expected bicarbonate derived from the delta gap). Assuming a baseline normal anion gap of 12 mEq/L12 \text{ mEq/L}, what is this patient's delta-adjusted bicarbonate (in mEq/L)?

Answer: 40 mEq/L

Answer

40
The delta-adjusted bicarbonate is calculated to uncover hidden metabolic disorders in the setting of a high anion gap metabolic acidosis (HAGMA). First, the anion gap (AG) is calculated as Na+−(Cl−+HCO3−)=140−(88+24)=28 mEq/LNa^+ - (Cl^- + HCO_3^-) = 140 - (88 + 24) = 28 \text{ mEq/L}. The excess anion gap (delta gap) is the measured AG minus the normal AG: 28−12=16 mEq/L28 - 12 = 16 \text{ mEq/L}. The delta-adjusted bicarbonate is the measured bicarbonate plus the delta gap: 24+16=40 mEq/L24 + 16 = 40 \text{ mEq/L}. A delta-adjusted bicarbonate > 26 mEq/L26 \text{ mEq/L} indicates a concurrent metabolic alkalosis, which in this patient is caused by severe vomiting (loss of H+H^+ and Cl−Cl^-), completely offsetting the acidemia from diabetic ketoacidosis and resulting in a falsely normal pH.

Step-by-Step Solution

1
Calculate the measured Anion Gap (AG).
AG = 28 mEq/L
AG is required to determine the presence of high anion gap metabolic acidosis (HAGMA) and to calculate the delta gap.
2
Calculate the Delta Gap.
Delta Gap = 16 mEq/L
The delta gap represents the amount of unmeasured anions (acid) consuming the bicarbonate.
3
Calculate the Delta-adjusted Bicarbonate.
Delta-adjusted Bicarbonate = 40 mEq/L
Adding the delta gap back to the measured bicarbonate reveals what the bicarbonate level would be if the HAGMA were not present, exposing concurrent acid-base disorders.

Key Concept

Delta-Delta Gap Calculation for Mixed Acid-Base Disorders
Estimated Time:2m 0s
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