Arrange the following metabolic events in sequential order, starting from the initial activation of glucose in the cytoplasm to the production of acetyl-CoA inside the mitochondrion during aerobic cellular respiration.
- 1Phosphorylation of hexose sugar using ATP to form fructose-1,6-bisphosphate.
- 2Cleavage of the six-carbon intermediate into two three-carbon triose phosphate molecules.
- 3Oxidation of triose phosphate, reducing to and adding inorganic phosphate.
- 4Substrate-level phosphorylation yielding ATP and generating pyruvate.
- 5Oxidative decarboxylation of pyruvate in the mitochondrial matrix to form acetyl-CoA and release .
Cevap
The correct sequence of events is: Phosphorylation of hexose sugar using ATP to form fructose-1,6-bisphosphate → Cleavage of the six-carbon intermediate into two three-carbon triose phosphate molecules → Oxidation of triose phosphate, reducing to and adding inorganic phosphate → Substrate-level phosphorylation yielding ATP and generating pyruvate → Oxidative decarboxylation of pyruvate in the mitochondrial matrix to form acetyl-CoA and release .
Aerobic respiration begins in the cytoplasm with glycolysis. First, glucose is phosphorylated by ATP to form fructose-1,6-bisphosphate. Second, this 6-carbon molecule is split into two 3-carbon triose phosphate molecules. Third, triose phosphate is oxidized, transferring electrons to to generate . Fourth, energy payoff via substrate-level phosphorylation produces ATP and leaves pyruvate as the cytosolic end-product. Finally, pyruvate moves into the mitochondrial matrix to undergo oxidative decarboxylation (the link reaction), forming acetyl-CoA and releasing carbon dioxide.
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Anahtar Kavram
Sequential biochemical steps of glycolysis and the link reaction in aerobic respiration